Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan
نویسندگان
چکیده
منابع مشابه
Surveillance for neuraminidase-inhibitor-resistant influenza viruses in Japan, 1996-2007.
BACKGROUND High usage of the neuraminidase inhibitor (NAI) oseltamivir in Japan since 2003 led the Neuraminidase Inhibitor Susceptibility Network to assess the susceptibility of community isolates of influenza viruses to oseltamivir and zanamivir. METHODS Isolates were tested by the enzyme inhibition assay and by neuraminidase (NA) sequence analysis. RESULTS Among 1,141 A(H3N2) viruses and ...
متن کاملIdentification of Neuraminidase Gene Mutations of Influenza A/H3N2 Isolates in Mazandaran Province, 2016-2018
Background and purpose: Influenza is one of the viral infections of the respiratory system, which causes death in high-risk groups every year. The genomic changes of influenza virus make it susceptible to drug resistance, therefore, continuous monitoring of the influenza virus is highly important in order to recognize the efficacy of available drugs. The current study investigated the neuramin...
متن کاملSurveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia.
Two hundred and forty-five human influenza A and B viruses isolated in Australia between 1996 and 2003 were tested for their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir using a fluorescence-based neuraminidase inhibition assay. Based on mean IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influ...
متن کاملCharacterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations.
OBJECTIVES AND METHODS An influenza B virus plasmid-based rescue system was used to introduce site-specific mutations, previously observed in neuraminidase (NA) inhibitor-resistant viruses, into the NA protein of six recombinant viruses. Three mutations observed only among in vitro selected zanamivir-resistant influenza A mutants were introduced into the B/Beijing/1/87 virus NA protein, to chan...
متن کاملImpact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds.
Subtype-specific neuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) have been reported during in vitro passages and in clinic. In this study, we evaluated the impact of various NA mutations (E119A/G/V, H274Y, R292K and N294S) on the susceptibility profiles to different NAIs (oseltamivir, zanamivir and peramivir) using recombinant NA proteins of influenza A/WSN/33 (H1N1) ...
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ژورنال
عنوان ژورنال: Influenza and Other Respiratory Viruses
سال: 2019
ISSN: 1750-2640,1750-2659
DOI: 10.1111/irv.12624